Psilocybe angustipleurocystidiata is a relatively rare mushroom native to the forests of Mexico. It is mainly found in the Pine and Birch forests of the Mexican states of Mexico, Morelos and Veracruz, where it most commonly grows from red-clay soil. This species prefers high humidity and equally high elevations, rarely found below 1800 metres.
It may also rarely be found in Colombia, however it shares a similar appearance with other Psilocybe species, as well as range and habitat preferences. P. zapotecorum can only be differentiated with a microscope and P. muliercula may actually be the same species (contentiously). Like these two species, P. angustipleurocystidiata is known to contain psilocybin and psilocin, though in currently unknown levels.
These active compounds has made it amenable to spiritual, ritualistic, visionary and even medicinal uses by certain Mexican natives. In the village of Tetela del Volcan, near the Popocatepetl Volcano, there was one of the few historical references made to the use of this fungus in the treatment of stomach aches and toothaches. In the same area, they were equally used as a divinitory tool in ancient ceremonies.
Little is known about P. angustipleurocystidiata, at least in the world of science. While ethnobotanists and mycologists have begun to discover its traits, the modern shamans and healers of Mexico likely know this species well.